Cell Based Assays are a mainstay of drug development and scientific research, but growth is now accelerating as new immuno-oncology markets create unprecedented investment in the race to cure cancer. On top of this new technology is allowing Cell Based Assays to be used to measure any aspect of cell function. This market just keeps on growing with no end in sight. The workhorse of the pharmaceutical industry is becoming a central player in biotechnology.
This is a complex area but this readable report will bring the entire management team up to speed, on both the technology and the opportunity.
The technology is moving faster than the market. Genomics and Immunology are playing a role too. Find opportunities and pitfalls. Understand growth expectations and the ultimate potential market size.
Key Topics Covered
1. Introduction and Market Definition 1.1 What are Cell Based Assays? 1.2 Clinical Trial Failures 1.2.1 Immuno-oncology Plays a Leading Role in Cell Based Assays 1.3 Market Definition 1.3.1 Market Size 1.3.2 Currency 1.3.3 Years 1.4 Methodology 1.4.1 Authors 1.4.2 Sources 1.5 U.S. Medical Market and Pharmaceutical Research Spending - Perspective 1.5.1 U.S. Expenditures for Pharmaceutical Research
2. Cell Based Assays - Guide to Technology 2.1 Cell Cultures 2.1.1 Cell Lines 2.1.2 Primary Cells 2.1.3 Stem Cells 2.1.3.1 iPSC's - The Special Case 2.2 Cell Assays 2.3 Cell Viability Assays 2.3 Cell Proliferation Assays 2.4 Cytotoxicity Assays 2.5 Cell Senescence Assays 2.6 Apoptosis 2.7 Autophagy 2.8 Necrosis 2.9 Oxidative Stress 2.10 2D vs. 3D 2.11 Signalling Pathways, GPCR 2.12 Immune Regulation & Inhibition 2.13 Reporter Gene Technology 2.14 CBA Design & Development 2.15 Cell Based Assays - The Takeaway
3. Industry Overview 3.1 Players in a Dynamic Market 3.1.1 Academic Research Lab 3.1.2 Contract Research Organization 3.1.3 Genomic Instrumentation Supplier 3.1.5 Cell Line and Reagent Supplier 3.1.6 Pharmaceutical Company 3.1.7 Audit Body 3.1.8 Certification Body
4. Market Trends 4.1 Factors Driving Growth 4.1.1 Candidate Growth 4.1.2 Immuno-oncology 4.1.3 Genomic Blizzard 4.1.4 Technology Convergence 4.1.5 The Insurance Effect 4.2 Factors Limiting Growth 4.2.1 CBA Development Challenges 4.2.2 Instrument Integration 4.2.3 Protocols 4.3 Technology Development 4.3.1 3D Assays 4.3.2 Automation 4.3.3 Software 4.3.4 Primary Cells 4.3.5 Signalling and Reporter Genes 4.3.6 The Next Five Years
5. Cell Based Assays Recent Developments 5.1 Recent Developments - Importance and How to Use This Section 5.1.1 Importance of These Developments 5.1.2 How to Use This Section
High-throughput Identifies cancer drug candidates
Velabs Therapeutics partners with Alytas Therapeutics to develop a novel immune-based therapy for obesity
InSphero platform selected to test Cyclerion's sGC stimulator technology
OcellO to provide in vitro research services to Merus
ACEA Biosciences to be Acquired by Agilent Technologies
Olympus announces new 3D Cell Analysis technology
Beckman Coulter Launches Flow Cytometry Software
Agilent Technologies Inc. and BioTek Instruments, Inc to Create Integrated Metabolic Analysis and Imaging Platform
Molecular Devices launches new features for ImageXpress Pico
Automated Cell Imaging System
Ncardia Launches Custom CRISPR Gene-editing in iPSC-derived Cell
Lines with Horizon Discovery as Partner
MilliporeSigma to sell Flow Cytometry Unit
Charles River Laboratories purchases Nanion Syncropatch 384PE
Reaction Biology and Promega announce new NanoBRET Technology
Nanion Technologies and Ncardia to enhance Options for Cardiac Researchers
Citoxlab signs deal with Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO)
Battery Ventures Acquires TTP Labtech Limited
BD Launches Cell Sorter to Enable Sorting of Rare Cell Types
Enzo Life Sciences Introduces Validated Antibodies for IHC
Sartorius launches new high throughput bioreactor system
6. Profiles of Key Cell Based Assay Companies
Abcam
Agilent
Beckman Coulter, Inc.
Becton Dickinson
BioIVT
Bio-Rad Laboratories, Inc.
BioTek Instruments
BioVision, Inc.
Cell Biolabs, Inc
Cell Signaling Technology, Inc.
Charles River Laboratories, Inc.
Cisbio Bioassays
Corning, Inc
Cytovale
Enzo Life Sciences, Inc.
Eurofins DiscoverX Corporation
Evotec AG
Excellerate Bioscience
Fujifilm Cellular Dynamics International
GE Healthcare Life Sciences
Hemogenix
Horizon Discovery Group plc
Invivogen
Leica Biosystems
Lonza Group Ltd.
Merck KgaA
Miltenyi Biotec
Molecular Devices
Nanion
Ncardia
New England Biolabs, Inc
Olympus
Origene Technologies
PerkinElmer, Inc
Promega Corporation
Qiagen NV
Reaction Biology
Roche Group
Sartorius
Sony Biotechnology
Stemcells Technologies Canada Inc.
Thermo Fisher Scientific, Inc.
TTP Labtech
Vitro Biopharma
7. Global Market Size 7.1 Cell Based Assay Global Market Size by Region with Charts 7.2 Cell Based Assays Global Market Size by Type with Charts
8. Global Market by User Type 8.1 Pharmaceutical Market 8.1.1 Pharmaceutical Market by Region with Chart 8.2 Basic Research Market 8.2.1 Basic Research Market by Region with Chart 8.3 Industrial/Cosmetic Market 8.3.1 Industrial/Cosmetic Market by Region with Chart
9. Cell Based Assay by Product Class 9.1 Instrument Market 9.1.1 Instrument Market by Region with Chart 9.2 Reagent Market 9.2.1 Reagent Market by Region with Chart 9.3 Services Market 9.3.1 Services Market by Region with Chart 9.4 Software Market 9.4.1 Software Market by Region with Chart
10. Appendices 10.1 FDA Cancer Drug Approvals by Year 10.2 Clinical Trials Started 2010 to 2016 10.3 Share of Pharma R&D by Country
Companies Mentioned
Abcam
ACEA Biosciences
Agilent Technologies
Alytas Therapeutics
Battery Ventures
Beckman Coulter, Inc.
Becton Dickinson
Bio-Rad Laboratories, Inc.
BioIVT
Biological Specialty Corporation
BioTek Instruments, Inc
BioVision, Inc.
Calico Biolabs
Cell Biolabs, Inc
Cell Signaling Technology, Inc.
Charles River Laboratories, Inc.
Cisbio
Citoxlab
Clinical Trials Laboratory Services
Corning, Inc
Cyclerion
Cytovale
Enzo Life Sciences, Inc.
Eurofins DiscoverX Corporation
Evotec AG
Excellerate Bioscience
Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO)
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