Major US equities traded mixed during Wednesday's premarket, after United States House of Representatives Speaker Nancy Pelosi's controversial visit to Taiwan and announcement of a possible trade deal. During the day, CVS Health Corp., Moderna, and eBay were set to publish their quarterly reports.

The Dow Jones increased by 0.22% at 4:12 am ET, while the Nasdaq 100 fell 0.18%. The S&P 500 stood flat at 4:13 am ET. The euro was up by 13% against the dollar at 4:13 am ET to sell for 1.01811.